Hydrogel Bioadhesives with Extreme Acid?Tolerance for Gastric Perforation Repairing

Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing repairing, owing their unique advantages in biocompatibility, mechanical compliance, minimally invasive manipulation. However, only a few hydrogel been successfully used gastric perforation repair, due undesirable swelling when direct contact with extremely acidic fluids, are thereby accompanied by gradually deteriorating adhesion performance. Herein, an acid-tolerant (ATGel) bioadhesive is developed, which integrates two distinct components, substrate adhesive polymer brush layer. The ATGel can form instant, atraumatic, fluid-tight, sutureless perforation, enable robust biointerfaces addressing key limitations commercially-available tissue adhesives. Moreover, vivo investigation on rat model validates proposed bioadhesion, identifies mechanisms accelerated repair through alleviated inflammation, suppresses fibrosis enhances angiogenesis.